解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Producing keratinocyte cells (KCs) in large scale is difficult due to their slow proliferation, disabling their use as seed cells for skin regeneration and wound healing. Cell reprogramming is a promising inducer-based approach to KC production but only reaches very low cellular conversion. Here we reported a unique c...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.31526
更新日期:2019-07-09 00:00:00
abstract::Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote the metastatic potential of specific cancer cells in a CD36-dependent manner. However, the molecular basis of the fatty acid (FA)-induced upregulation of CD36 has remained unclear. Met...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.34024
更新日期:2019-07-09 00:00:00
abstract::Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field still suffers from poor data reproducibility. This is especially true in cases of infants, conside...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.31502
更新日期:2019-06-19 00:00:00
abstract::Rationale: Tumor metastasis is the main cause for cancer-related death. However, the driving molecules of metastasis remain largely unknown. Here, we aim to identify long non-coding RNAs (lncRNAs) critical for human hepatocellular carcinoma (HCC) metastasis. Methods: Microarrays were used to screen a comprehensive set...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.32854
更新日期:2019-06-09 00:00:00
abstract::The ability of brain tissue to regenerate is limited; therefore, brain diseases (i.e., trauma, stroke, tumors) often lead to irreversible motor and cognitive impairments. Therapeutic interventions using various types of injectable biomaterials have been investigated to promote endogenous neural differentiation. Despit...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.35606
更新日期:2019-05-31 00:00:00
abstract::Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed a site-specific, combination nanotherapy strategy for targeted treatment of CAC by the oral route. Methods: A reactive oxygen species (ROS)...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.34377
更新日期:2019-05-31 00:00:00
abstract::Background: Metastasis is the major reason for high recurrence rates and poor survival among patients with colorectal cancer (CRC). However, the underlying molecular mechanism of CRC metastasis is unclear. This study aimed to investigate the role of forkhead box K2 (FOXK2), one of the most markedly increased FOX genes...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.31716
更新日期:2019-05-31 00:00:00
abstract::Heart diseases are one of the leading causes of death for humans in the world. Increasing evidence has shown that myocardial injury induced innate and adaptive immune responses upon early cellular damage but also during chronic phases post-injury. The immune cells can not only aggravate the injury but also play an ess...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.33112
更新日期:2019-05-31 00:00:00
abstract::Cerebrospinal fluid (CSF) leakage can lead to brain and spine pathologies and there is an urgent need for a rapid diagnostic method for determining CSF leakage. Beta-2 transferrin (β2TF), asialotransferrin, is a specific CSF glycoprotein biomarker used to determine CSF leakage when distinguished from serum sialotransf...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.34411
更新日期:2019-05-31 00:00:00
abstract::Emerging evidence indicates that reprogramming of energy metabolism involving disturbances in energy production from a defect in cellular respiration with a shift to glycolysis is a core hallmark of cancer. Alterations in cancer cell energy metabolism are linked to abnormalities in mitochondrial function. Mitochondria...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33100
更新日期:2019-05-26 00:00:00
abstract::Rationale: The overall success rate of prostate cancer (PCa) diagnosis and therapy has been improved over the years. However, genomic and phenotypic heterogeneity remains a major challenge for effective detection and treatment of PCa. Efforts to better classify PCa into functional subtypes and elucidate the molecular ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33292
更新日期:2019-05-24 00:00:00
abstract::Using non-covalent interactions between nucleic acids (DNA, siRNA, miRNA, and mRNA) with peptides or nucleopeptides is a promising strategy to construct supramolecular assemblies for gene delivery and therapy. Comparing to conventional strategies for gene delivery, the assemblies of peptides or nucleopeptides provide ...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.31854
更新日期:2019-05-18 00:00:00
abstract::Host-guest motifs are likely the most recognizable manifestation of supramolecular chemistry. These complexes are characterized by the organization of small molecules on the basis of preferential association of a guest within the portal of a host. In the context of their therapeutic use, the primary application of the...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.31913
更新日期:2019-05-15 00:00:00
abstract::Transcription factor FOXM1 is involved in stimulating cell proliferation, enhancing DNA damage repair, promoting metastasis of cancer cells, and the inhibition of FOXM1 has been shown to prevent the initiation and progression of multiple cancers and FOXM1 is considered to be an effective target for tumor therapeutic d...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.32693
更新日期:2019-04-25 00:00:00
abstract::The delivery of therapeutics into tumors remains a challenge in nanoparticle-mediated drug delivery. However, effective therapies such as photothermal therapy (PTT) are limited by quick systemic clearance and non-specific biodistribution. Anti-tumor strategies tailored to accommodate both tumor accumulation/retention ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33280
更新日期:2019-04-13 00:00:00
abstract::Rationale: Within the field of personalized medicine there is an increasing focus on designing flexible, multifunctional drug delivery systems that combine high efficacy with minimal side effects, by tailoring treatment to the individual. Methods: We synthesized a chemically stabilized ~4 nm nucleic acid nanoscaffold,...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.32060
更新日期:2019-04-13 00:00:00
abstract::SIRT6, NAD+-dependent deacetylase sirtuin 6, has recently shown to suppress tumor growth in several types of cancer. Colon cancer is a challenging carcinoma associated with high morbidity and death. However, whether SIRT6 play a direct role in colon tumorigenesis and the underlying mechanism are not understood. Method...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29724
更新日期:2019-04-13 00:00:00
abstract::The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian clock on intestinal MRP2, and to determine the molecular mechanisms for generation of diurnal MRP2 expression. Methods: The regulatory effects of Bmal1 on inte...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.33395
更新日期:2019-04-13 00:00:00
abstract::Marfan syndrome (MFS) is a rare genetic disease characterized by a matrix metalloproteases (MMPs) dysregulation that leads to extracellular matrix degradation. Consequently, MFS patients are prone to develop progressive thoracic aortic enlargement and detrimental aneurysm. Since MMPs are activated by the extracellular...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.30714
更新日期:2019-04-12 00:00:00
abstract::Rationale: Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (hiPSCs) have been developed to address the shortage of primary human hepatocytes (PHHs) for therapeutic applications. However, the in vivo repopulation capacity of HLCs remains limited. This study investigated the roles of agoni...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.30009
更新日期:2019-04-06 00:00:00
abstract::Rationale: The incidence of hepatocellular carcinoma is rising worldwide. It is predicted that nearly half of the early-stage hepatocellular carcinoma (E-HCC) patients will develop recurrence. Dysregulated pH, a hallmark of E-HCC, is correlated with poor prognosis. The acidic microenvironment has been shown to promote...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.30958
更新日期:2019-03-16 00:00:00
abstract::Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug delivery vectors due to their biological origin and inherent intercellular biomolecule delivery capability. An in-depth knowledge of their in vivo biodistribution is therefore essential. This work aimed to develop a novel, reli...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27891
更新日期:2019-02-28 00:00:00
abstract::Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27313
更新日期:2019-02-28 00:00:00
abstract::Rationale: Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor alpha (ER-α), human epidermal growth factor receptor 2 (HER2) and progesterone receptor (PR) expression, but the effect of lacking the three factors on TNBC is unclear. Whether loss of the three factors contributes to ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.30701
更新日期:2019-02-20 00:00:00
abstract::The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Novel blood-based markers may help to overcome this...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29247
更新日期:2019-02-12 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is a transmembrane cell surface receptor that is frequently overexpressed and/or mutated in many cancers. Therapies targeting EGFR have poor outcomes due to the lack of reliable diagnostic tests to monitor EGFR. Current in vitro EGFR diagnostic methods are invasive, requiring bi...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.30835
更新日期:2019-01-30 00:00:00
abstract::Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatm...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29566
更新日期:2019-01-30 00:00:00
abstract::Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive. Nanog is a master transcriptional regulator of stemness, especially in CSCs. I...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29271
更新日期:2019-01-24 00:00:00
abstract::Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represents a model of chronic hypoxia. Development of the lymphatic network ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27794
更新日期:2019-01-21 00:00:00
abstract::The therapeutic efficacy of fluorescence image-guided tumor surgery and photodynamic therapy (PDT) is impaired by the penetration depth limitation, low signal-to-noise ratio of traditional first near-infrared window (NIR I) fluorescence and the hypoxic tumor microenvironment. Here, a "red blood cell-based multimodal p...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29817
更新日期:2019-01-01 00:00:00
abstract::Molecular photoacoustic imaging (PA) is a promising technology to understand tumor pathology and guide precision therapeutics. Despite the capability of activatable PA probes to image tumor-specific biomarkers, limitations in their molecular structure hamper them from effective drug delivery and the drug release monit...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.30779
更新日期:2019-01-01 00:00:00
abstract::Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting cognitive processes. Monitor...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29740
更新日期:2019-01-01 00:00:00
abstract::Radiotherapy is an extensively used treatment modality in the clinic and can kill malignant cells by generating cytotoxic reactive oxygen species (ROS). Unfortunately, excessive dosages of radiation are typically required because only a small proportion of the radiative energy is adsorbed by the soft tissues of a tumo...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.28033
更新日期:2019-01-01 00:00:00
abstract::Exosomes (Exo) secreted from hypoxia-conditioned bone marrow mesenchymal stem cells (BM-MSCs) were found to be protective for ischemic disease. However, the role of exosomal miRNA in the protective effect of hypoxia-conditioned BM-MSCs-derived Exo (Hypo-Exo) remains largely uncharacterized and the poor specificity of ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.28021
更新日期:2018-11-29 00:00:00
abstract::Cancer theranostics is one of the most important approaches for detecting and treating patients at an early stage. To develop such a technique, accurate detection, specific targeting, and controlled delivery are the key components. Various kinds of nanoparticles have been proposed and demonstrated as potential nanoveh...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.27828
更新日期:2018-11-29 00:00:00
abstract::The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...
journal_title:Theranostics
pub_type: 评论,社论
doi:10.7150/thno.29864
更新日期:2018-11-15 00:00:00
abstract::Inadequate diagnostic methods for prostate cancer lead to over- and undertreatment, and the inability to intraoperatively visualize positive margins may limit the success of surgical resection. Prostate cancer visualization could be improved by combining the complementary modalities of immuno-positron emission tomogra...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27679
更新日期:2018-11-12 00:00:00
abstract::Molecular subtyping of breast cancer is of considerable interest owing to its potential for personalized therapy and prognosis. However, current methodologies cannot be used for precise subtyping, thereby posing a challenge in clinical practice. The aim of the present study is to develop a cell-specific single-strande...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.28949
更新日期:2018-11-10 00:00:00
abstract::Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels in vivo is therefore of paramount importance when assessing the efficacy of copper-targeting drugs. ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.29840
更新日期:2018-11-09 00:00:00
abstract::The limited clinical efficacy of monotherapies in the clinic has urged the development of novel combination platforms. Taking advantage of light-triggered photodynamic treatment combined together with the controlled release of nanomedicine, it has been possible to treat cancer without eliciting any adverse effects. Ho...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27721
更新日期:2018-11-03 00:00:00